Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the RAS from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. In the unusual case that there is no appropriate alternative to therapy with drugs affecting the RAS for a particular patient, apprise the mother of the potential risk to the fetus.
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Perform serial ultrasound examinations to assess the intra-amniotic environment. If oligohydramnios is observed, discontinue amlodipine and benazepril hydrochloride capsules, unless they are considered lifesaving for the mother. Fetal testing may be appropriate, based on the week of pregnancy. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury.
Closely observe infants with histories of in utero exposure to amlodipine besylate and benazepril hydrochloride for hypotension, oliguria, and hyperkalemia [see Use in Specific Populations 8.
Limit the dose of simvastatin in patients on amlodipine to 20 mg daily. Monitor for symptoms of hypotension and edema when amlodipine is coadministered with CYP3A4 inhibitors to determine the need for dose adjustment. Blood pressure should be monitored when amlodipine is coadministered with CYP3A4 inducers.kindtimidirsi.gq
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Benazepril Potassium Supplements and Potassium-Sparing Diuretics: Benazepril can attenuate potassium loss caused by thiazide diuretics. Potassium-sparing diuretics spironolactone, amiloride, triamterene, and others or potassium supplements can increase the risk of hyperkalemia. Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium.
When coadministering amlodipine besylate and benazepril hydrochloride and lithium, frequent monitoring of serum lithium levels is recommended. Gold: Nitritoid reactions symptoms include facial flushing, nausea, vomiting and hypotension have been reported rarely in patients on therapy with injectable gold sodium aurothiomalate and concomitant ACE inhibitor therapy.
These effects are usually reversible.
Antidiabetic Agents: In rare cases, diabetic patients receiving an ACE inhibitor including benazepril concomitantly with insulin or oral antidiabetics may develop hypoglycemia. Such patients should therefore be advised about the possibility of hypoglycemic reactions, and should be monitored accordingly.
Dual Blockade of the Renin-Angiotensin System RAS : Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy.
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In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on amlodipine besylate and benazepril hydrochloride and other agents that block the RAS. Do not coadminister aliskiren with amlodipine besylate and benazepril hydrochloride in patients with diabetes.
Amlodipine and benazepril hydrochloride capsules are indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent. The antihypertensive effect of a single dose persisted for 24 hours, with peak reductions achieved 2 to 8 hours after dosing. Combination therapy was effective in blacks and nonblacks. Both components contributed to the antihypertensive efficacy in nonblacks, but virtually all of the antihypertensive effect in blacks could be attributed to the amlodipine component. Among nonblack patients in placebo-controlled trials comparing amlodipine and benazepril hydrochloride capsules to the individual components, the blood pressure lowering effects of the combination were shown to be additive and in some cases synergistic.
During chronic therapy with amlodipine and benazepril hydrochloride capsules, the maximum reduction in blood pressure with any given dose is generally achieved after 1 to 2 weeks. The antihypertensive effects of amlodipine and benazepril hydrochloride capsules have continued during therapy for at least 1 year.
Abrupt withdrawal of amlodipine and benazepril hydrochloride capsules has not been associated with a rapid increase in blood pressure. These reactions usually occur after one of the first few doses of the ACE inhibitor, but they sometimes do not appear until after months of therapy. Black patients receiving ACE inhibitors have a higher incidence of angioedema compared to nonblacks. Head and Neck Angioedema: Angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors.
Angioedema associated with laryngeal edema can be fatal. If laryngeal stridor or angioedema of the face, tongue, or glottis occurs, discontinue treatment with amlodipine and benazepril hydrochloride capsules and treat immediately. When involvement of the tongue, glottis, or larynx appears likely to cause airway obstruction, appropriate therapy, e. Intestinal Angioedema: Intestinal angioedema has been reported in patients treated with ACE inhibitors.
These patients presented with abdominal pain with or without nausea or vomiting ; in some cases there was no prior history of facial angioedema and C-1 esterase levels were normal. The angioedema was diagnosed by procedures including abdominal CT scan or ultrasound, or at surgery, and symptoms resolved after stopping the ACE inhibitor. Intestinal angioedema should be included in the differential diagnosis of patients on ACE inhibitors presenting with abdominal pain. Anaphylactoid Reactions During Desensitization: Two patients undergoing desensitizing treatment with hymenoptera wasp sting venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions.
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Keep this plastic drug discount coupon in your wallet so that you can easily use it whenever you fill a prescription at most any pharmacy. Note, it is possible to ask your doctor for prescriptions for over-the-counter medicines. My Rx was cheaper than my insurance co-pay with the Coupon! Amlodipine and Benazepril is a combination of two drugs, a calcium channel blocker amlodipine and an ACE inhibitor benazepril.
It works by relaxing blood vessels so that blood can flow more easily. Amlodipine and Benazepril is used to treat high blood pressure. Amlodipine and Benazepri offers are usually a printable coupon, rebate, savings card, trial offer, or free samples offered directly by the manufacturer. Some offers may be printed right from a website, while others require that you complete a registration or questionnaire. Patient assistance programs PAPs are usually sponsored by pharmaceutical companies and provide free or discounted medicines to low income or uninsured and under-insured people who meet specific guidelines.
Eligibility requirements vary for each program. Oftentimes, there are cost-savings tips for various drugs that you can take advantage of as a consumer, such as pill-splitting, which can help you save money on your prescription drug costs. You may also find that filling a day supply will reduce your total cost for this prescription.
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Common side effects of Amlodipine and Benazepril may include confusion, dizziness, fast or irregular heartbeat, nervousness, numbness in the feet, hands or lips, shortness of breath, weakness or heaviness of the legs. Contact your doctor if you experience any of these side effects. Amlodipine and Benazepril contains the active ingredients amlodipine besylate and benazepril hydrochloride. Usual initial dose for Amlodipine is 2. Maintenance dose for Amlodipine is 2.
Consult with your physician to determine the best dosage for you. Long term use of Amlodipine is known to cause dizziness, stomach pain, flushing, and fatigue. Patients with history of heart diseases such as aortic stenosis and congestive heart failure, low blood pressure, as well as liver disease should consult a doctor first before ingesting this drug, as prolonged intake of the said substance is said to worsen the mentioned pre-existing conditions. No studies prove that intake is harmful for pregnant women and their unborn child, but precaution in the form of physician consultation is still recommended.
Amlodipine has several known drug interactions which should be avoided in fear of serious side effects which could prove to be lethal at some point. If you are taking medication such as Zocor, Simcor, Vytorin, heart or blood pressure medications, then it is advised that you consult your doctor first in order to know some alternatives which could work better for your situation.
What Amlodipine does is antagonize the activities of dihydropyridine calcium which serves as an obstacle to the movement of calcium ions into vascular smooth muscle cells as well as cardiac muscle cells.